IGF2BP1 induces neuroblastoma via a druggable feedforward loop with MYCN promoting 17q oncogene expression

BACKGROUND: Neuroblastoma is the most common solid tumor in infants accounting for approximately 15% of all cancer-related deaths. Over 50% of high-risk neuroblastoma relapse, emphasizing the need of novel drug targets and therapeutic strategies. In neuroblastoma, chromosomal gains at chromosome 17q...

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Detalles Bibliográficos
Autores principales: Hagemann, Sven, Misiak, Danny, Bell, Jessica L., Fuchs, Tommy, Lederer, Marcell I., Bley, Nadine, Hämmerle, Monika, Ghazy, Ehab, Sippl, Wolfgang, Schulte, Johannes H., Hüttelmaier, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226260/
https://www.ncbi.nlm.nih.gov/pubmed/37246217
http://dx.doi.org/10.1186/s12943-023-01792-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226260/
https://www.ncbi.nlm.nih.gov/pubmed/37246217
http://dx.doi.org/10.1186/s12943-023-01792-0

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