Empagliflozin reduces arrhythmogenic effects in rat neonatal and human iPSC-derived cardiomyocytes and improves cytosolic calcium handling at least partially independent of NHE1

The antidiabetic agent class of sodium-glucose cotransporter 2 (SGLT2) inhibitors confer unprecedented cardiovascular benefits beyond glycemic control, including reducing the risk of fatal ventricular arrhythmias. However, the impact of SGLT2 inhibitors on the electrophysiological properties of card...

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Detalles Bibliográficos
Autores principales: Silva dos Santos, Danúbia, Turaça, Lauro Thiago, Coutinho, Keyla Cristiny da Silva, Barbosa, Raiana Andrade Quintanilha, Polidoro, Juliano Zequini, Kasai-Brunswick, Tais Hanae, Campos de Carvalho, Antonio Carlos, Girardi, Adriana Castello Costa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226982/
https://www.ncbi.nlm.nih.gov/pubmed/37248416
http://dx.doi.org/10.1038/s41598-023-35944-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10226982/
https://www.ncbi.nlm.nih.gov/pubmed/37248416
http://dx.doi.org/10.1038/s41598-023-35944-5

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