Streptozotocin induces renal proximal tubular injury through p53 signaling activation

Streptozotocin (STZ), an anti-cancer drug that is primarily used to treat neuroendocrine tumors (NETs) in clinical settings, is incorporated into pancreatic β-cells or proximal tubular epithelial cells through the glucose transporter, GLUT2. However, its cytotoxic effects on kidney cells have been u...

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Detalles Bibliográficos
Autores principales: Nakai, Kunihiro, Umehara, Minato, Minamida, Atsushi, Yamauchi-Sawada, Hiroko, Sunahara, Yasuto, Matoba, Yayoi, Okuno-Ozeki, Natsuko, Nakamura, Itaru, Nakata, Tomohiro, Yagi-Tomita, Aya, Uehara-Watanabe, Noriko, Ida, Tomoharu, Yamashita, Noriyuki, Kamezaki, Michitsugu, Kirita, Yuhei, Konishi, Eiichi, Yasuda, Hiroaki, Matoba, Satoaki, Tamagaki, Keiichi, Kusaba, Tetsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227064/
https://www.ncbi.nlm.nih.gov/pubmed/37248327
http://dx.doi.org/10.1038/s41598-023-35850-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227064/
https://www.ncbi.nlm.nih.gov/pubmed/37248327
http://dx.doi.org/10.1038/s41598-023-35850-w

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