Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis

Inhibitors of triacylglycerol (TG) synthesis have been developed to treat metabolism-related diseases, but we know little about their mechanisms of action. Here, we report cryo-EM structures of the TG-synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a membrane bound O-acyltransfer...

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Detalles Bibliográficos
Autores principales: Sui, Xuewu, Wang, Kun, Song, Kangkang, Xu, Chen, Song, Jiunn, Lee, Chia-Wei, Liao, Maofu, Farese, Robert V., Walther, Tobias C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227072/
https://www.ncbi.nlm.nih.gov/pubmed/37248213
http://dx.doi.org/10.1038/s41467-023-38934-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227072/
https://www.ncbi.nlm.nih.gov/pubmed/37248213
http://dx.doi.org/10.1038/s41467-023-38934-3

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