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Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis
Inhibitors of triacylglycerol (TG) synthesis have been developed to treat metabolism-related diseases, but we know little about their mechanisms of action. Here, we report cryo-EM structures of the TG-synthesis enzyme acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1), a membrane bound O-acyltransfer...
Autores principales: | Sui, Xuewu, Wang, Kun, Song, Kangkang, Xu, Chen, Song, Jiunn, Lee, Chia-Wei, Liao, Maofu, Farese, Robert V., Walther, Tobias C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227072/ https://www.ncbi.nlm.nih.gov/pubmed/37248213 http://dx.doi.org/10.1038/s41467-023-38934-3 |
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