CYX-5, a G-protein biassed MOP receptor agonist, DOP receptor antagonist and KOP receptor agonist, evokes constipation but not respiratory depression relative to morphine in rats

BACKGROUND: Strong opioid analgesics such as morphine alleviate moderate to severe acute nociceptive pain (e.g. post-surgical or post-trauma pain) as well as chronic cancer pain. However, they evoke many adverse effects and so there is an unmet need for opioid analgesics with improved tolerability....

Descripción completa

Detalles Bibliográficos
Autores principales: Imam, Mohammad Zafar, Kuo, Andy, Ghassabian, Sussan, Cai, Yunxin, Qin, Yajuan, Li, Tingyou, Smith, Maree T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227131/
https://www.ncbi.nlm.nih.gov/pubmed/36637684
http://dx.doi.org/10.1007/s43440-023-00446-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227131/
https://www.ncbi.nlm.nih.gov/pubmed/36637684
http://dx.doi.org/10.1007/s43440-023-00446-8

Ejemplares similares