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Troponin-I–induced tropomyosin pivoting defines thin-filament function in relaxed and active muscle

Regulation of the crossbridge cycle that drives muscle contraction involves a reconfiguration of the troponin–tropomyosin complex on actin filaments. By comparing atomic models of troponin–tropomyosin fitted to cryo-EM structures of inhibited and Ca(2+)-activated thin filaments, we find that tropomy...

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Detalles Bibliográficos
Autores principales:	Lehman, William, Rynkiewicz, Michael J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Rockefeller University Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10227645/ https://www.ncbi.nlm.nih.gov/pubmed/37249525 http://dx.doi.org/10.1085/jgp.202313387

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