Biotransformation and brain distribution of the anti-COVID-19 drug molnupiravir and herb-drug pharmacokinetic interactions between the herbal extract Scutellaria formula-NRICM101

The aim of this study was to explore the effects of herbal drug pharmacokinetic interactions on the biotransformation of molnupiravir and its metabolite β-D-N4-hydroxycytidine (NHC) in the blood and brain. To investigate the biotransformation mechanism, a carboxylesterase inhibitor, bis(4-nitropheny...

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Detalles Bibliográficos
Autores principales: Chang, Chun-Hao, Peng, Wen-Ya, Lee, Wan-Hsin, Lin, Tung-Yi, Yang, Muh-Hwa, Dalley, Jeffrey W., Tsai, Tung-Hu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228170/
https://www.ncbi.nlm.nih.gov/pubmed/37302376
http://dx.doi.org/10.1016/j.jpba.2023.115499

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228170/
https://www.ncbi.nlm.nih.gov/pubmed/37302376
http://dx.doi.org/10.1016/j.jpba.2023.115499

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