A modular RNA delivery system comprising spherical nucleic acids built on endosome-escaping polymeric nanoparticles

Nucleic acid therapeutics require delivery systems to reach their targets. Key challenges to be overcome include avoidance of accumulation in cells of the mononuclear phagocyte system and escape from the endosomal pathway. Spherical nucleic acids (SNAs), in which a gold nanoparticle supports a coron...

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Detalles Bibliográficos
Autores principales: Garcia-Guerra, Antonio, Ellerington, Ruth, Gaitzsch, Jens, Bath, Jonathan, Kye, Mahnseok, Varela, Miguel A., Battaglia, Giuseppe, Wood, Matthew J. A., Manzano, Raquel, Rinaldi, Carlo, Turberfield, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: RSC 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228346/
https://www.ncbi.nlm.nih.gov/pubmed/37260495
http://dx.doi.org/10.1039/d2na00846g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228346/
https://www.ncbi.nlm.nih.gov/pubmed/37260495
http://dx.doi.org/10.1039/d2na00846g

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