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A widely used pan-isoform-FBXW7 antibody used in cell cycle studies does not detect FBXW7
FBXW7 is the substrate recognition component of the E3 ubiquitin ligase SCF(FBW7) complex which controls the levels of CYCLINE, c-MYC and HIF1α proteins crucial for cell growth and differentiation. Mutations in FBXW7 are frequently associated with tumourigenesis. While examining FBXW7 regulation we...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228410/ https://www.ncbi.nlm.nih.gov/pubmed/37183425 http://dx.doi.org/10.1080/15384101.2023.2210044 |