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Obstructive sleep apnea in a mouse model is associated with tissue-specific transcriptomic changes in circadian rhythmicity and mean 24-hour gene expression
Intermittent hypoxia (IH) is a major clinical feature of obstructive sleep apnea (OSA). The mechanisms that become dysregulated after periods of exposure to IH are unclear, particularly in the early stages of disease. The circadian clock governs a wide array of biological functions and is intimately...
Autores principales: | Koritala, Bala S. C., Lee, Yin Yeng, Gaspar, Laetitia S., Bhadri, Shweta S., Su, Wen, Wu, Gang, Francey, Lauren J., Ruben, Marc D., Gong, Ming C., Hogenesch, John B., Smith, David F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10228805/ https://www.ncbi.nlm.nih.gov/pubmed/37252926 http://dx.doi.org/10.1371/journal.pbio.3002139 |
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