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Hypermetabolism in mice carrying a near-complete human chromosome 21

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The consequences of aneuploidy have traditionally been studied in cell and animal models in which the extrachromosomal DNA is from the same species. Here, we explore a fundamental question concerning the impact of aneuploidy on systemic metabolism using a non-mosaic transchromosomic mouse model (TcM...

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Detalles Bibliográficos
Autores principales:	Sarver, Dylan C, Xu, Cheng, Rodriguez, Susana, Aja, Susan, Jaffe, Andrew E, Gao, Feng J, Delannoy, Michael, Periasamy, Muthu, Kazuki, Yasuhiro, Oshimura, Mitsuo, Reeves, Roger H, Wong, G William
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2023
Materias:	Chromosomes and Gene Expression
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229126/ https://www.ncbi.nlm.nih.gov/pubmed/37249575 http://dx.doi.org/10.7554/eLife.86023

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