Combinatorial protein dimerization enables precise multi-input synthetic computations

Bacterial transcription factors (TFs) with helix-turn-helix (HTH) DNA-binding domains have been widely explored to build orthogonal transcriptional regulation systems in mammalian cells. Here we capitalize on the modular structure of these proteins to build a framework for multi-input logic gates re...

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Detalles Bibliográficos
Autores principales: Bertschi, Adrian, Wang, Pengli, Galvan, Silvia, Teixeira, Ana Palma, Fussenegger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229424/
https://www.ncbi.nlm.nih.gov/pubmed/36894721
http://dx.doi.org/10.1038/s41589-023-01281-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229424/
https://www.ncbi.nlm.nih.gov/pubmed/36894721
http://dx.doi.org/10.1038/s41589-023-01281-x

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