Site-specific encoding of photoactivity and photoreactivity into antibody fragments

Design of biomolecules that perform two or more distinct functions in response to light remains challenging. Here, we have introduced concurrent photoactivity and photoreactivity into an epidermal growth factor receptor (EGFR)-targeting antibody fragment, 7D12. This was achieved by site-specific inc...

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Detalles Bibliográficos
Autores principales: Bridge, Thomas, Wegmann, Udo, Crack, Jason C., Orman, Kate, Shaikh, Saher A., Farndon, William, Martins, Carlo, Saalbach, Gerhard, Sachdeva, Amit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229432/
https://www.ncbi.nlm.nih.gov/pubmed/36797401
http://dx.doi.org/10.1038/s41589-022-01251-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229432/
https://www.ncbi.nlm.nih.gov/pubmed/36797401
http://dx.doi.org/10.1038/s41589-022-01251-9

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