Cargando…

Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality

Mostrar otras versiones (1)

Cardiovascular disease (CVD) is a multisystemic and multicellular pathology that is generally associated with high levels of atherogenic lipoproteins in circulation. These lipoproteins tend to be retained and modified, for example, aggregated low-density lipoprotein (aggLDL), in the extracellular ma...

Descripción completa

Detalles Bibliográficos
Autores principales:	Actis Dato, Virginia, Paz, María C., Rey, Federico E., Sánchez, María C., Llorente-Cortés, Vicenta, Chiabrando, Gustavo A., Ceschin, Danilo G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229538/ https://www.ncbi.nlm.nih.gov/pubmed/37253991 http://dx.doi.org/10.1038/s41598-023-35951-6

Ejemplares similares

Transcriptional analysis reveals that the intracellular lipid accumulation impairs gene expression profiles involved in insulin response-associated cardiac functionality
por: Dato, Virginia Actis, et al.
Publicado: (2023)

LRP1-Mediated AggLDL Endocytosis Promotes Cholesteryl Ester Accumulation and Impairs Insulin Response in HL-1 Cells
por: Actis Dato, Virginia, et al.
Publicado: (2020)

Activated Alpha-2 Macroglobulin Improves Insulin Response via LRP1 in Lipid-Loaded HL-1 Cardiomyocytes
por: Actis Dato, Virginia, et al.
Publicado: (2021)

The Role of Low-Density Lipoprotein Receptor-Related Protein 1 in Lipid Metabolism, Glucose Homeostasis and Inflammation
por: Actis Dato, Virginia, et al.
Publicado: (2018)

LRP1 mediates the IGF-1-induced GLUT1 expression on the cell surface and glucose uptake in Müller glial cells
por: Actis Dato, Virginia, et al.
Publicado: (2021)

Inhibitory Effects of LRP1-Based Immunotherapy on Cardiac Extracellular Matrix Biophysical Alterations Induced by Hypercholesterolemia
por: Samouillan, Valerie, et al.
Publicado: (2023)

Nitro-oleic acid, a ligand of CD36, reduces cholesterol accumulation by modulating oxidized-LDL uptake and cholesterol efflux in RAW264.7 macrophages
por: Vazquez, Matias M., et al.
Publicado: (2020)

Activated α(2)-Macroglobulin Regulates LRP1 Levels at the Plasma Membrane through the Activation of a Rab10-dependent Exocytic Pathway in Retinal Müller Glial Cells
por: Jaldín-Fincati, Javier R., et al.
Publicado: (2019)

Decreased low-density lipoprotein receptor-related protein 1 expression in pro-inflammatory monocytes is associated with subclinical atherosclerosis
por: Albertini, Ricardo A., et al.
Publicado: (2022)

Excess Accumulation of Lipid Impairs Insulin Sensitivity in Skeletal Muscle
por: Park, Sung Sup, et al.
Publicado: (2020)

Heme accumulation in endothelial cells impairs angiogenesis by triggering paraptosis
por: Petrillo, Sara, et al.
Publicado: (2017)

Candesartan, an angiotensin-II receptor blocker, ameliorates insulin resistance and hepatosteatosis by reducing intracellular calcium overload and lipid accumulation
por: Lee, Jin Wook, et al.
Publicado: (2023)

Metabolic Syndrome Triggered by Fructose Diet Impairs Neuronal Function and Vascular Integrity in ApoE-KO Mouse Retinas: Implications of Autophagy Deficient Activation
por: Paz, María C., et al.
Publicado: (2020)

Cell surface heparan sulfate proteoglycans contribute to intracellular lipid accumulation in adipocytes
por: Wilsie, Larissa C, et al.
Publicado: (2005)

GRIM-19 Restricts HCV Replication by Attenuating Intracellular Lipid Accumulation
por: Kim, Jung-Hee, et al.
Publicado: (2017)

Fasudil Increased the Sensitivity to Gefitinib in NSCLC by Decreasing Intracellular Lipid Accumulation
por: Liao, Tingting, et al.
Publicado: (2022)

Accumulation of saturated intramyocellular lipid is associated with insulin resistance
por: Savage, David B., et al.
Publicado: (2019)

Effect of intracellular lipid accumulation in a new model of non-alcoholic fatty liver disease
por: Chavez-Tapia, Norberto C, et al.
Publicado: (2012)

Peptides against Low Density Lipoprotein (LDL) Aggregation Inhibit Intracellular Cholesteryl Ester Loading and Proliferation of Pancreatic Tumor Cells
por: Benitez-Amaro, Aleyda, et al.
Publicado: (2022)

PLIN5 deletion remodels intracellular lipid composition and causes insulin resistance in muscle
por: Mason, Rachael R., et al.
Publicado: (2014)

Multitarget Activities of Müller Glial Cells and Low-Density Lipoprotein Receptor-Related Protein 1 in Proliferative Retinopathies
por: Sanchez, María C., et al.
Publicado: (2022)

Insensitivity to atorvastatin is associated with increased accumulation of intracellular lipid droplets and fatty acid metabolism in breast cancer cells
por: Lettiero, Barbara, et al.
Publicado: (2018)

Lipid droplets are intracellular mechanical stressors that impair hepatocyte function
por: Loneker, Abigail E., et al.
Publicado: (2023)

Insulin-induced lipid body accumulation is accompanied by lipid remodelling in model mast cells
por: Aldan, Johnny T., et al.
Publicado: (2019)

Lipid-Encapsuled Grape Tannins Prevent Oxidative-Stress-Induced Neuronal Cell Death, Intracellular ROS Accumulation and Inflammation
por: Díaz, Hugo S., et al.
Publicado: (2022)

Ectopic fat accumulation in human astrocytes impairs insulin action
por: Heni, Martin, et al.
Publicado: (2020)

Enhanced Nrf2 Activity Worsens Insulin Resistance, Impairs Lipid Accumulation in Adipose Tissue, and Increases Hepatic Steatosis in Leptin-Deficient Mice
por: Xu, Jialin, et al.
Publicado: (2012)

Insulin activates intracellular transport of lipid droplets to release triglycerides from the liver
por: Kumar, Mukesh, et al.
Publicado: (2019)

Low density lipoprotein receptor-related protein 1 expression correlates with cholesteryl ester accumulation in the myocardium of ischemic cardiomyopathy patients
por: Cal, Roi, et al.
Publicado: (2012)

Association of intracellular lipid accumulation in subcutaneous adipocyte precursors and plasma adipokines in bariatric surgery candidates
por: Hristov, Ioana, et al.
Publicado: (2019)

Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy
por: Tanner, Lloyd, et al.
Publicado: (2021)

Intratumor cholesteryl ester accumulation is associated with human breast cancer proliferation and aggressive potential: a molecular and clinicopathological study
por: de Gonzalo-Calvo, David, et al.
Publicado: (2015)

Rottlerin Stimulates Exosome/Microvesicle Release Via the Increase of Ceramide Levels Mediated by Ampk in an In Vitro Model of Intracellular Lipid Accumulation
por: Molina, Yessenia L., et al.
Publicado: (2022)

Excessive Accumulation of Intracellular Ca(2+) After Acute Exercise Potentiated Impairment of T-cell Function
por: Liu, Renyi, et al.
Publicado: (2021)

Impaired Retromer Function in Niemann-Pick Type C Disease Is Dependent on Intracellular Cholesterol Accumulation
por: Dominko, Kristina, et al.
Publicado: (2021)

Carbon Black Nanoparticles Promote Endothelial Activation and Lipid Accumulation in Macrophages Independently of Intracellular ROS Production
por: Cao, Yi, et al.
Publicado: (2014)

Mercury-Pollution Induction of Intracellular Lipid Accumulation and Lysosomal Compartment Amplification in the Benthic Foraminifer Ammonia parkinsoniana
por: Frontalini, Fabrizio, et al.
Publicado: (2016)

The marine‐derived furanone reduces intracellular lipid accumulation in vitro by targeting LXRα and PPARα
por: Li, Ting, et al.
Publicado: (2020)

Intracellular lipid droplet accumulation occurs early following viral infection and is required for an efficient interferon response
por: Monson, E. A., et al.
Publicado: (2021)

Label-Free Raman Spectromicroscopy Unravels the Relationship between MGMT Methylation and Intracellular Lipid Accumulation in Glioblastoma
por: Wang, Nana, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_qfo9slaqp4l1sj4ap54vbbrf10