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Transcriptional coactivation by EHMT2 restricts glucocorticoid-induced insulin resistance in a study with male mice

The classical dogma of glucocorticoid-induced insulin resistance is that it is caused by the transcriptional activation of hepatic gluconeogenic and insulin resistance genes by the glucocorticoid receptor (GR). Here, we find that glucocorticoids also stimulate the expression of insulin-sensitizing g...

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Detalles Bibliográficos
Autores principales: Lee, Rebecca A., Chang, Maggie, Yiv, Nicholas, Tsay, Ariel, Tian, Sharon, Li, Danielle, Poulard, Coralie, Stallcup, Michael R., Pufall, Miles A., Wang, Jen-Chywan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229547/
https://www.ncbi.nlm.nih.gov/pubmed/37253782
http://dx.doi.org/10.1038/s41467-023-38584-5