Insulin-like growth factor binding protein-3 induces senescence by inhibiting telomerase activity in MCF-7 breast cancer cells

Insulin-like growth factor binding protein-3 (IGFBP-3) has been known to inhibit cell proliferation and exert tumor-suppressing effects depending on the cell type. In this study, we aimed to show that IGFBP-3 induces cellular senescence via suppression of the telomerase activity, thereby inhibiting...

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Detalles Bibliográficos
Autores principales: Kwon, Ahreum, Chae, Hyun Wook, Lee, Woo Jung, Kim, JungHyun, Kim, Ye Jin, Ahn, Jungmin, Oh, Youngman, Kim, Ho-Seong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229562/
https://www.ncbi.nlm.nih.gov/pubmed/37253773
http://dx.doi.org/10.1038/s41598-023-35291-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229562/
https://www.ncbi.nlm.nih.gov/pubmed/37253773
http://dx.doi.org/10.1038/s41598-023-35291-5

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