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Skin gluten-related disorders: new and old cutaneous manifestations to be considered

The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large varie...

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Autores principales: Verdelli, Alice, Corrà, Alberto, Mariotti, Elena Biancamaria, Aimo, Cristina, Quintarelli, Lavinia, Ruffo di Calabria, Valentina, Donati, Marta Elettra, Bonciolini, Veronica, Antiga, Emiliano, Caproni, Marzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229844/
https://www.ncbi.nlm.nih.gov/pubmed/37265490
http://dx.doi.org/10.3389/fmed.2023.1155288
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author Verdelli, Alice
Corrà, Alberto
Mariotti, Elena Biancamaria
Aimo, Cristina
Quintarelli, Lavinia
Ruffo di Calabria, Valentina
Donati, Marta Elettra
Bonciolini, Veronica
Antiga, Emiliano
Caproni, Marzia
author_facet Verdelli, Alice
Corrà, Alberto
Mariotti, Elena Biancamaria
Aimo, Cristina
Quintarelli, Lavinia
Ruffo di Calabria, Valentina
Donati, Marta Elettra
Bonciolini, Veronica
Antiga, Emiliano
Caproni, Marzia
author_sort Verdelli, Alice
collection PubMed
description The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a “cutaneous-gluten sensitivity,” as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS.
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spelling pubmed-102298442023-06-01 Skin gluten-related disorders: new and old cutaneous manifestations to be considered Verdelli, Alice Corrà, Alberto Mariotti, Elena Biancamaria Aimo, Cristina Quintarelli, Lavinia Ruffo di Calabria, Valentina Donati, Marta Elettra Bonciolini, Veronica Antiga, Emiliano Caproni, Marzia Front Med (Lausanne) Medicine The term gluten-related disorders (GRD) refer to a spectrum of different clinical manifestations triggered by the ingestion of gluten in genetically susceptible individuals, including coeliac disease (CD), wheat allergy and non-celiac gluten sensitivity (NCGS). GRD are characterized by a large variety of clinical presentations with both intestinal and extra-intestinal manifestations. The latter may affect almost every organ of the body, including the skin. Besides the well-known association between CD and dermatitis herpetiformis, considered as the cutaneous specific manifestation of CD, many other muco-cutaneous disorders have been associated to GRD. In this review, we analyzed the main features of dermatological diseases with a proven association with GRD and those that improve after a gluten-free diet, focusing on the newly described cutaneous manifestations associated with NCGS. Our main hypothesis is that a “cutaneous-gluten sensitivity,” as specific cutaneous manifestation of NCGS, may exist and could represent a diagnostic marker of NCGS. Frontiers Media S.A. 2023-05-17 /pmc/articles/PMC10229844/ /pubmed/37265490 http://dx.doi.org/10.3389/fmed.2023.1155288 Text en Copyright © 2023 Alice, Corrà, Mariotti, Aimo, Quintarelli, Ruffo di Calabria, Elettra Donati, Bonciolini, Antiga and Caproni. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Verdelli, Alice
Corrà, Alberto
Mariotti, Elena Biancamaria
Aimo, Cristina
Quintarelli, Lavinia
Ruffo di Calabria, Valentina
Donati, Marta Elettra
Bonciolini, Veronica
Antiga, Emiliano
Caproni, Marzia
Skin gluten-related disorders: new and old cutaneous manifestations to be considered
title Skin gluten-related disorders: new and old cutaneous manifestations to be considered
title_full Skin gluten-related disorders: new and old cutaneous manifestations to be considered
title_fullStr Skin gluten-related disorders: new and old cutaneous manifestations to be considered
title_full_unstemmed Skin gluten-related disorders: new and old cutaneous manifestations to be considered
title_short Skin gluten-related disorders: new and old cutaneous manifestations to be considered
title_sort skin gluten-related disorders: new and old cutaneous manifestations to be considered
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10229844/
https://www.ncbi.nlm.nih.gov/pubmed/37265490
http://dx.doi.org/10.3389/fmed.2023.1155288
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