Mitochondrial pyruvate dehydrogenase kinases contribute to platelet function and thrombosis in mice by regulating aerobic glycolysis

Resting platelets rely on oxidative phosphorylation (OXPHOS) and aerobic glycolysis (conversion of glucose to lactate in the presence of oxygen) for their energy requirements. In contrast, platelet activation exhibits an increased rate of aerobic glycolysis relative to OXPHOS. Mitochondrial enzymes...

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Detalles Bibliográficos
Autores principales: Flora, Gagan D., Nayak, Manasa K., Ghatge, Madankumar, Kumskova, Mariia, Patel, Rakesh B., Chauhan, Anil K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Platelets and Thrombopoiesis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230171/
https://www.ncbi.nlm.nih.gov/pubmed/36971790
http://dx.doi.org/10.1182/bloodadvances.2023010100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230171/
https://www.ncbi.nlm.nih.gov/pubmed/36971790
http://dx.doi.org/10.1182/bloodadvances.2023010100

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