Synthesis of novel entecavir analogues having 4′-cyano-6′′-fluoromethylenecyclopentene skeletons as an aglycone moiety as highly potent and long-acting anti-hepatitis B virus agent

Encouraged by our recent findings that 4′-cyano-deoxyguanosine (2), entecavir analogues 4 and 5 are highly potent anti-hepatitis B virus (HBV) agents, we designed and synthesized 6 having a hybridized structure of 4 and 5. The chiral quaternary carbon portion at the 4′-position, which is substituted...

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Detalles Bibliográficos
Autores principales: Kumamoto, Hiroki, Higashi-Kuwata, Nobuyo, Hayashi, Sanae, Das, Debananda, Bulut, Haydar, Tokuda, Ryoh, Imoto, Shuhei, Onitsuka, Kengo, Honda, Yuka, Odanaka, Yuki, Shimbara-Matsubayashi, Satoko, Haraguchi, Kazuhiro, Tanaka, Yasuhito, Mitsuya, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230191/
https://www.ncbi.nlm.nih.gov/pubmed/37265996
http://dx.doi.org/10.1039/d3ra01750h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230191/
https://www.ncbi.nlm.nih.gov/pubmed/37265996
http://dx.doi.org/10.1039/d3ra01750h

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