Concomitant targeting of FLT3 and BTK overcomes FLT3 inhibitor resistance in acute myeloid leukemia through the inhibition of autophagy

Strategies to overcome resistance to FMS-like tyrosine kinase 3 (FLT3)-targeted therapy in acute myeloid leukemia (AML) are urgently needed. We identified autophagy as one of the resistance mechanisms, induced by hypoxia and the bone marrow microenvironment via activation of Bruton tyrosine kinase (...

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Detalles Bibliográficos
Autores principales: Zhang, Weiguo, Yu, Guopan, Zhang, Hongying, Basyal, Mahesh, Ly, Charlie, Yuan, Bin, Ruvolo, Vivian, Piya, Sujan, Bhattacharya, Seemana, Zhang, Qi, Borthakur, Gautam, Battula, Venkata L., Konopleva, Marina, Rice, William G., Andreeff, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2022
Materias:
Article - Acute Myeloid Leukemia
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230429/
https://www.ncbi.nlm.nih.gov/pubmed/36226489
http://dx.doi.org/10.3324/haematol.2022.280884

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230429/
https://www.ncbi.nlm.nih.gov/pubmed/36226489
http://dx.doi.org/10.3324/haematol.2022.280884

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