Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy

Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus...

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Detalles Bibliográficos
Autores principales: Jacobs, Jana L, Haidar, Ghady, Naqvi, Asma, McCormick, Kevin D, Sobolewski, Michele, Treat, Benjamin R, Heaps, Amy L, Simpson, Jordan, Kramer, Kailey Hughes, McCreary, Erin, Bariola, J Ryan, Klamar-Blain, Cynthia, Macatangay, Bernard J C, Dimitrov, Dimiter, Li, Wei, Marino, Christopher C, Raptis, Anastasios, Sethi, Rahil, Chandran, Uma, Barratt-Boyes, Simon, Parikh, Urvi M, Mellors, John W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230564/
https://www.ncbi.nlm.nih.gov/pubmed/37265667
http://dx.doi.org/10.1093/ofid/ofad278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230564/
https://www.ncbi.nlm.nih.gov/pubmed/37265667
http://dx.doi.org/10.1093/ofid/ofad278

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