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Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy
Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230564/ https://www.ncbi.nlm.nih.gov/pubmed/37265667 http://dx.doi.org/10.1093/ofid/ofad278 |
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| author | Jacobs, Jana L Haidar, Ghady Naqvi, Asma McCormick, Kevin D Sobolewski, Michele Treat, Benjamin R Heaps, Amy L Simpson, Jordan Kramer, Kailey Hughes McCreary, Erin Bariola, J Ryan Klamar-Blain, Cynthia Macatangay, Bernard J C Dimitrov, Dimiter Li, Wei Marino, Christopher C Raptis, Anastasios Sethi, Rahil Chandran, Uma Barratt-Boyes, Simon Parikh, Urvi M Mellors, John W |
| author_facet | Jacobs, Jana L Haidar, Ghady Naqvi, Asma McCormick, Kevin D Sobolewski, Michele Treat, Benjamin R Heaps, Amy L Simpson, Jordan Kramer, Kailey Hughes McCreary, Erin Bariola, J Ryan Klamar-Blain, Cynthia Macatangay, Bernard J C Dimitrov, Dimiter Li, Wei Marino, Christopher C Raptis, Anastasios Sethi, Rahil Chandran, Uma Barratt-Boyes, Simon Parikh, Urvi M Mellors, John W |
| author_sort | Jacobs, Jana L |
| collection | PubMed |
| description | Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus was isolated from respiratory secretions, suggesting the potential for secondary transmission. |
| format | Online Article Text |
| id | pubmed-10230564 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Oxford University Press |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-102305642023-06-01 Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy Jacobs, Jana L Haidar, Ghady Naqvi, Asma McCormick, Kevin D Sobolewski, Michele Treat, Benjamin R Heaps, Amy L Simpson, Jordan Kramer, Kailey Hughes McCreary, Erin Bariola, J Ryan Klamar-Blain, Cynthia Macatangay, Bernard J C Dimitrov, Dimiter Li, Wei Marino, Christopher C Raptis, Anastasios Sethi, Rahil Chandran, Uma Barratt-Boyes, Simon Parikh, Urvi M Mellors, John W Open Forum Infect Dis Brief Report Prolonged coronavirus disease 2019 may generate new viral variants. We report an immunocompromised patient treated with monoclonal antibodies who experienced rebound of viral RNA and emergence of an antibody-resistant (>1000-fold) variant containing 5 mutations in the spike gene. The mutant virus was isolated from respiratory secretions, suggesting the potential for secondary transmission. Oxford University Press 2023-05-17 /pmc/articles/PMC10230564/ /pubmed/37265667 http://dx.doi.org/10.1093/ofid/ofad278 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
| spellingShingle | Brief Report Jacobs, Jana L Haidar, Ghady Naqvi, Asma McCormick, Kevin D Sobolewski, Michele Treat, Benjamin R Heaps, Amy L Simpson, Jordan Kramer, Kailey Hughes McCreary, Erin Bariola, J Ryan Klamar-Blain, Cynthia Macatangay, Bernard J C Dimitrov, Dimiter Li, Wei Marino, Christopher C Raptis, Anastasios Sethi, Rahil Chandran, Uma Barratt-Boyes, Simon Parikh, Urvi M Mellors, John W Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy |
| title | Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy |
| title_full | Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy |
| title_fullStr | Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy |
| title_full_unstemmed | Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy |
| title_short | Rapid Emergence of Potentially Transmissible Severe Acute Respiratory Syndrome Coronavirus 2 With Resistance to Combination Monoclonal Antibody Therapy |
| title_sort | rapid emergence of potentially transmissible severe acute respiratory syndrome coronavirus 2 with resistance to combination monoclonal antibody therapy |
| topic | Brief Report |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230564/ https://www.ncbi.nlm.nih.gov/pubmed/37265667 http://dx.doi.org/10.1093/ofid/ofad278 |
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