Honokiol attenuates acetaminophen-induced acute liver injury by inhibiting hepatic CYP1A2 activity and improving liver mitochondrial dysfunction

OBJECTIVE: Acetaminophen (APAP) overdose is a common cause of liver injury. This study aimed to investigate the protective effect of honokiol (Hon) against APAP-induced hepatotoxicity and its potential mechanism. METHODS: C57BL/6 mice were administrated with Hon (10 and 30 mg/kg) after APAP (300 mg/...

Descripción completa

Detalles Bibliográficos
Autores principales: Miao, Xiaolei, Jin, Chengting, Liu, Jiao, Wang, Junjun, Chen, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230637/
https://www.ncbi.nlm.nih.gov/pubmed/37265773
http://dx.doi.org/10.1016/j.chmed.2023.01.002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230637/
https://www.ncbi.nlm.nih.gov/pubmed/37265773
http://dx.doi.org/10.1016/j.chmed.2023.01.002

Ejemplares similares