Cargando…

Engineering Oncolytic Coxsackievirus A21 with Small Transgenes and Enabling Cell-Mediated Virus Delivery by Integrating Viral cDNA into the Genome

Coxsackievirus A21 (CVA21) is a naturally occurring RNA virus that, in preclinical studies and clinical trials, has demonstrated promising potential in treating a range of malignancies. Other oncolytic viruses, such as adenovirus, vesicular stomatitis virus, herpesvirus, and vaccinia virus, all can...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sam, Miranda, Selman, Mohammed, Zhao, Weilong, Jung, Jiwon, Willingham, Aarron, Phan, Uyen, Starling, Gary C., Gao, Qinshan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2023
Materias:	Gene Delivery
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231226/ https://www.ncbi.nlm.nih.gov/pubmed/37070982 http://dx.doi.org/10.1128/jvi.00309-23

Ejemplares similares

A Strategy for Cultivation of Retargeted Oncolytic Herpes Simplex Viruses in Non-cancer Cells
por: Leoni, Valerio, et al.
Publicado: (2017)

Simultaneous Insertion of Two Ligands in gD for Cultivation of Oncolytic Herpes Simplex Viruses in Noncancer Cells and Retargeting to Cancer Receptors
por: Leoni, Valerio, et al.
Publicado: (2018)

Oncolytic Foamy Virus: Generation and Properties of a Nonpathogenic Replicating Retroviral Vector System That Targets Chronically Proliferating Cancer Cells
por: Budzik, Karol M., et al.
Publicado: (2021)

Dual Ligand Insertion in gB and gD of Oncolytic Herpes Simplex Viruses for Retargeting to a Producer Vero Cell Line and to Cancer Cells
por: Petrovic, Biljana, et al.
Publicado: (2018)

Complementary Effects of Interleukin-15 and Alpha Interferon Induce Immunity in Hepatitis B Virus Transgenic Mice
por: Di Scala, Marianna, et al.
Publicado: (2016)

Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach
por: Havlik, L. Patrick, et al.
Publicado: (2020)

A New Gorilla Adenoviral Vector with Natural Lung Tropism Avoids Liver Toxicity and Is Amenable to Capsid Engineering and Vector Retargeting
por: Lu, Zhi Hong, et al.
Publicado: (2020)

Human AdV-20-42-42, a Promising Novel Adenoviral Vector for Gene Therapy and Vaccine Product Development
por: Ballmann, Mónika Z., et al.
Publicado: (2021)

BST2 Suppresses LINE-1 Retrotransposition by Reducing the Promoter Activity of LINE-1 5′ UTR
por: Zhao, Yifei, et al.
Publicado: (2022)

Adeno-associated Virus (AAV) Capsid Chimeras with Enhanced Infectivity Reveal a Core Element in the AAV Genome Critical for both Cell Transduction and Capsid Assembly
por: Viney, Lydia, et al.
Publicado: (2021)

Characterization and biodistribution of under-employed gene therapy vector AAV7
por: Yost, Samantha A., et al.
Publicado: (2023)

Prior Exposure to Coxsackievirus A21 Does Not Mitigate Oncolytic Therapeutic Efficacy
por: Burnett, William J., et al.
Publicado: (2021)

Oncolytic immunotherapy for the treatment of non-muscle invasive bladder cancer using intravesical coxsackievirus A21
por: Annels, Nicola E, et al.
Publicado: (2015)

Coxsackievirus B3—Its Potential as an Oncolytic Virus
por: Geisler, Anja, et al.
Publicado: (2021)

Construction and characterization of an infectious cDNA clone of coxsackievirus A 10
por: Liu, Qiliang, et al.
Publicado: (2019)

Construction and verification of an infectious cDNA clone of coxsackievirus B5
por: Song, Lifang, et al.
Publicado: (2022)

Plasmacytoid dendritic cells orchestrate innate and adaptive anti-tumor immunity induced by oncolytic coxsackievirus A21
por: Müller, Louise M. E., et al.
Publicado: (2019)

Development of Group B Coxsackievirus as an Oncolytic Virus: Opportunities and Challenges
por: Liu, Huitao, et al.
Publicado: (2021)

SEC coupled with in-line multiple detectors for the characterization of an oncolytic Coxsackievirus
por: Deng, James Z., et al.
Publicado: (2021)

2-Deoxyglucose, an Inhibitor of Glycolysis, Enhances the Oncolytic Effect of Coxsackievirus
por: Vorobyev, Pavel O., et al.
Publicado: (2022)

Synthesis of glycyrrhetinic acid-modified liposomes to deliver Murrayafoline A for treatment of hepatocellular carcinoma
por: Dinh, Cuc Thi, et al.
Publicado: (2022)

Clinician Adherence to Inflammatory Bowel Disease Guidelines: Results of a Qualitative Study of Barriers and Enablers
por: Kanazaki, Ria, et al.
Publicado: (2022)

Applications of coxsackievirus A21 in oncology
por: Bradley, Stephen, et al.
Publicado: (2014)

Immunostimulatory oncolytic activity of coxsackievirus A11 in human malignant pleural mesothelioma
por: Okamura, Koji, et al.
Publicado: (2022)

Application Route and Immune Status of the Host Determine Safety and Oncolytic Activity of Oncolytic Coxsackievirus B3 Variant PD-H
por: Hazini, Ahmet, et al.
Publicado: (2021)

Phase I/II storm study: Intravenous delivery of a novel oncolytic immunotherapy agent, Coxsackievirus A21, in advanced cancer patients
por: Pandha, Hardev, et al.
Publicado: (2015)

Enhanced genomic stability of new miRNA-regulated oncolytic coxsackievirus B3
por: Liu, Huitao, et al.
Publicado: (2022)

DIRS retrotransposons amplify via linear, single-stranded cDNA intermediates
por: Malicki, Marek, et al.
Publicado: (2020)

Application of clotrimazole via a novel controlled release device provides potent retinal protection
por: Nezhad, Zhaleh Kashkouli, et al.
Publicado: (2015)

Nanoprecipitation of polymeric nanoparticle micelles based on 2-methacryloyloxyethyl phosphorylcholine (MPC) with 2-(diisopropylamino)ethyl methacrylate (DPA), for intracellular delivery applications
por: Salvage, Jonathan P., et al.
Publicado: (2015)

Synthesis and characterisation of cationic quaternary ammonium-modified polyvinyl alcohol hydrogel beads as a drug delivery embolisation system
por: Heaysman, Clare L., et al.
Publicado: (2016)

Spatio-temporal release of NGF and GDNF from multi-layered nanofibrous bicomponent electrospun scaffolds
por: Liu, Chaoyu, et al.
Publicado: (2018)

Carbon nanotubes play an important role in the spatial arrangement of calcium deposits in hydrogels for bone regeneration
por: Cancian, Giulia, et al.
Publicado: (2016)

14-3-3ε protein-loaded 3D hydrogels favor osteogenesis
por: Aldana, Ana A., et al.
Publicado: (2020)

Nanofibrous bicomponent scaffolds for the dual delivery of NGF and GDNF: controlled release of growth factors and their biological effects
por: Liu, Chaoyu, et al.
Publicado: (2021)

Cystatin-like protein of sweet orange (CsinCPI-2) modulates pre-osteoblast differentiation via β-Catenin involvement
por: da Costa Fernandes, Célio, et al.
Publicado: (2021)

Magnetic nanocarriers as a therapeutic drug delivery strategy for promoting pain-related motor functions in a rat model of cartilage transplantation
por: Zhang, Xingyu, et al.
Publicado: (2021)

Kinetics of ion release from a conventional glass-ionomer cement
por: Nicholson, John W., et al.
Publicado: (2021)

In situ drug release measuring in α-TCP cement by electrochemical impedance spectroscopy
por: Pasqual, Júnio Augusto Rodrigues, et al.
Publicado: (2021)

Multifunctional hybrid nanoplatform based on Fe(3)O(4)@Ag NPs for nitric oxide delivery: development, characterization, therapeutic efficacy, and hemocompatibility
por: Pieretti, Joana Claudio, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ghb7ipdsd21kklg3su300rvn9a