Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity

Heterozygous variants in the glucocerebrosidase (GBA) gene are common and potent risk factors for Parkinson’s disease (PD). GBA also causes the autosomal recessive lysosomal storage disorder (LSD), Gaucher disease, and emerging evidence from human genetics implicates many other LSD genes in PD susce...

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Detalles Bibliográficos
Autores principales: Yu, Meigen, Ye, Hui, De-Paula, Ruth B., Mangleburg, Carl Grant, Wu, Timothy, Lee, Tom V., Li, Yarong, Duong, Duc, Phillips, Bridget, Cruchaga, Carlos, Allen, Genevera I., Seyfried, Nicholas T., Al-Ramahi, Ismael, Botas, Juan, Shulman, Joshua M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231792/
https://www.ncbi.nlm.nih.gov/pubmed/37200393
http://dx.doi.org/10.1371/journal.pgen.1010760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231792/
https://www.ncbi.nlm.nih.gov/pubmed/37200393
http://dx.doi.org/10.1371/journal.pgen.1010760

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