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Reporting on FH-deficient renal cell carcinoma using circulating succinylated metabolites

Fumarate hydratase–deficient (FH-deficient) renal cell carcinoma (RCC) represents a particularly aggressive form of kidney cancer. FH-deficient RCC arises in the setting of germline, or solely somatic, mutations in the FH gene, a two-hit tumor suppressor gene. Early detection can be curative, but th...

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Detalles Bibliográficos
Autores principales: Bezwada, Divya, Brugarolas, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10231985/
https://www.ncbi.nlm.nih.gov/pubmed/37259915
http://dx.doi.org/10.1172/JCI170195