Circulating succinate-modifying metabolites accurately classify and reflect the status of fumarate hydratase–deficient renal cell carcinoma

Germline or somatic loss-of-function mutations of fumarate hydratase (FH) predispose patients to an aggressive form of renal cell carcinoma (RCC). Since other than tumor resection there is no effective therapy for metastatic FH-deficient RCC, an accurate method for early diagnosis is needed. Althoug...

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Detalles Bibliográficos
Autores principales: Zheng, Liang, Zhu, Zi-Ran, Sneh, Tal, Zhang, Wei-Tuo, Wang, Zao-Yu, Wu, Guang-Yu, He, Wei, Qi, Hong-Gang, Wang, Hang, Wu, Xiao-Yu, Fernández-García, Jonatan, Abramovich, Ifat, Xu, Yun-Ze, Zhang, Jin, Gottlieb, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232000/
https://www.ncbi.nlm.nih.gov/pubmed/37053010
http://dx.doi.org/10.1172/JCI165028

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232000/
https://www.ncbi.nlm.nih.gov/pubmed/37053010
http://dx.doi.org/10.1172/JCI165028

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