Silencing miR-21-5p in sensory neurons reverses neuropathic allodynia via activation of TGF-β–related pathway in macrophages

Neuropathic pain remains poorly managed by current therapies, highlighting the need to improve our knowledge of chronic pain mechanisms. In neuropathic pain models, dorsal root ganglia (DRG) nociceptive neurons transfer miR-21 packaged in extracellular vesicles to macrophages that promote a proinfla...

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Detalles Bibliográficos
Autores principales: Zeboudj, Lynda, Sideris-Lampretsas, George, Silva, Rita, Al-Mudaris, Sabeha, Picco, Francesca, Fox, Sarah, Chambers, David, Malcangio, Marzia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Clinical Investigation 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232007/
https://www.ncbi.nlm.nih.gov/pubmed/37071481
http://dx.doi.org/10.1172/JCI164472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232007/
https://www.ncbi.nlm.nih.gov/pubmed/37071481
http://dx.doi.org/10.1172/JCI164472

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