IQGAP1 promotes chronic pain by regulating the trafficking and sensitization of TRPA1 channels

TRPA1 channels have been implicated in mechanical and cold hypersensitivity in chronic pain. But how TRPA1 mediates this process is unclear. Here we show that IQ motif containing GTPase activating protein 1 is responsible using a combination of biochemical, molecular, Ca(2+) imaging and behavioural...

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Detalles Bibliográficos
Autores principales: Khan, Shakil, Patra, Pabitra Hriday, Somerfield, Hannah, Benya-Aphikul, Hattaya, Upadhya, Manoj, Zhang, Xuming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232262/
https://www.ncbi.nlm.nih.gov/pubmed/36477832
http://dx.doi.org/10.1093/brain/awac462

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232262/
https://www.ncbi.nlm.nih.gov/pubmed/36477832
http://dx.doi.org/10.1093/brain/awac462

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