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IQGAP1 promotes chronic pain by regulating the trafficking and sensitization of TRPA1 channels
TRPA1 channels have been implicated in mechanical and cold hypersensitivity in chronic pain. But how TRPA1 mediates this process is unclear. Here we show that IQ motif containing GTPase activating protein 1 is responsible using a combination of biochemical, molecular, Ca(2+) imaging and behavioural...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232262/ https://www.ncbi.nlm.nih.gov/pubmed/36477832 http://dx.doi.org/10.1093/brain/awac462 |