Uridine-derived ribose fuels glucose-restricted pancreatic cancer

Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy(1,2). This is mediated in part by a complex tumour microenvironment(3), low vascularity(4), and metabolic aberrations(5,6). Although altered metabolism drives tumour progression, the spectrum of metabolites u...

Descripción completa

Detalles Bibliográficos
Autores principales: Nwosu, Zeribe C., Ward, Matthew H., Sajjakulnukit, Peter, Poudel, Pawan, Ragulan, Chanthirika, Kasperek, Steven, Radyk, Megan, Sutton, Damien, Menjivar, Rosa E., Andren, Anthony, Apiz-Saab, Juan J., Tolstyka, Zachary, Brown, Kristee, Lee, Ho-Joon, Dzierozynski, Lindsey N., He, Xi, PS, Hari, Ugras, Julia, Nyamundanda, Gift, Zhang, Li, Halbrook, Christopher J., Carpenter, Eileen S., Shi, Jiaqi, Shriver, Leah P., Patti, Gary J., Muir, Alexander, Pasca di Magliano, Marina, Sadanandam, Anguraj, Lyssiotis, Costas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232363/
https://www.ncbi.nlm.nih.gov/pubmed/37198494
http://dx.doi.org/10.1038/s41586-023-06073-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232363/
https://www.ncbi.nlm.nih.gov/pubmed/37198494
http://dx.doi.org/10.1038/s41586-023-06073-w

Ejemplares similares