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Uridine-derived ribose fuels glucose-restricted pancreatic cancer
Pancreatic ductal adenocarcinoma (PDA) is a lethal disease notoriously resistant to therapy(1,2). This is mediated in part by a complex tumour microenvironment(3), low vascularity(4), and metabolic aberrations(5,6). Although altered metabolism drives tumour progression, the spectrum of metabolites u...
Autores principales: | Nwosu, Zeribe C., Ward, Matthew H., Sajjakulnukit, Peter, Poudel, Pawan, Ragulan, Chanthirika, Kasperek, Steven, Radyk, Megan, Sutton, Damien, Menjivar, Rosa E., Andren, Anthony, Apiz-Saab, Juan J., Tolstyka, Zachary, Brown, Kristee, Lee, Ho-Joon, Dzierozynski, Lindsey N., He, Xi, PS, Hari, Ugras, Julia, Nyamundanda, Gift, Zhang, Li, Halbrook, Christopher J., Carpenter, Eileen S., Shi, Jiaqi, Shriver, Leah P., Patti, Gary J., Muir, Alexander, Pasca di Magliano, Marina, Sadanandam, Anguraj, Lyssiotis, Costas A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232363/ https://www.ncbi.nlm.nih.gov/pubmed/37198494 http://dx.doi.org/10.1038/s41586-023-06073-w |
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