Data-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis

Challenging enantio- and diastereoselective cobalt-catalyzed C–H alkylation has been realized by an innovative data-driven knowledge transfer strategy. Harnessing the statistics of a related transformation as the knowledge source, the designed machine learning (ML) model took advantage of delta lear...

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Detalles Bibliográficos
Autores principales: Zhang, Zi-Jing, Li, Shu-Wen, Oliveira, João C. A., Li, Yanjun, Chen, Xinran, Zhang, Shuo-Qing, Xu, Li-Cheng, Rogge, Torben, Hong, Xin, Ackermann, Lutz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232535/
https://www.ncbi.nlm.nih.gov/pubmed/37258542
http://dx.doi.org/10.1038/s41467-023-38872-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232535/
https://www.ncbi.nlm.nih.gov/pubmed/37258542
http://dx.doi.org/10.1038/s41467-023-38872-0

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