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Data-driven design of new chiral carboxylic acid for construction of indoles with C-central and C–N axial chirality via cobalt catalysis

Challenging enantio- and diastereoselective cobalt-catalyzed C–H alkylation has been realized by an innovative data-driven knowledge transfer strategy. Harnessing the statistics of a related transformation as the knowledge source, the designed machine learning (ML) model took advantage of delta lear...

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Detalles Bibliográficos
Autores principales:	Zhang, Zi-Jing, Li, Shu-Wen, Oliveira, João C. A., Li, Yanjun, Chen, Xinran, Zhang, Shuo-Qing, Xu, Li-Cheng, Rogge, Torben, Hong, Xin, Ackermann, Lutz
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232535/ https://www.ncbi.nlm.nih.gov/pubmed/37258542 http://dx.doi.org/10.1038/s41467-023-38872-0

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