Class I HDAC inhibitor entinostat synergizes with PLK1 inhibitors in MYC-amplified medulloblastoma cells

PURPOSE: We and others have demonstrated that MYC-amplified medulloblastoma (MB) cells are susceptible to class I histone deacetylase inhibitor (HDACi) treatment. However, single drug treatment with HDACi has shown limited clinical efficacy. We hypothesized that addition of a second compound acting...

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Detalles Bibliográficos
Autores principales: Valinciute, Gintvile, Ecker, Jonas, Selt, Florian, Hielscher, Thomas, Sigaud, Romain, Ridinger, Johannes, Thatikonda, Venu, Gatzweiler, Charlotte, Robinson, Sarah, Talbot, Julie, Bernardi, Flavia, Picard, Daniel, Blattner-Johnson, Mirjam, Schmid, Simone, Jones, David T., van Tilburg, Cornelis M., Capper, David, Kool, Marcel, Remke, Marc, Oehme, Ina, Pfister, Stefan M., Roussel, Martine F., Ayrault, Olivier, Witt, Olaf, Milde, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232604/
https://www.ncbi.nlm.nih.gov/pubmed/37183219
http://dx.doi.org/10.1007/s11060-023-04319-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232604/
https://www.ncbi.nlm.nih.gov/pubmed/37183219
http://dx.doi.org/10.1007/s11060-023-04319-1

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