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Single-cell transcriptomics reveals ependymal subtypes related to cytoskeleton dynamics as the core driver of syringomyelia pathological development

Syringomyelia is a common clinical lesion associated with cerebrospinal fluid flow abnormalities. By a reversible model with chronic extradural compression to mimic human canalicular syringomyelia, we explored the spatiotemporal pathological alterations during syrinx development. The most dynamic al...

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Detalles Bibliográficos
Autores principales: Lu, Chunli, Wu, Xianming, Wang, Xinyu, Xiao, Zhifeng, Ma, Longbing, Dai, Jianwu, Jian, Fengzeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232665/
https://www.ncbi.nlm.nih.gov/pubmed/37275526
http://dx.doi.org/10.1016/j.isci.2023.106850