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The development of CD8 T-cell exhaustion heterogeneity and the therapeutic potentials in cancer

CD8(+) T cells are essential lymphocytes with cytotoxic properties for antitumor immunotherapy. However, during chronic infection or tumorigenesis, these cells often become dysfunctional with a gradually depleted ability to release cytokines and the exhibition of reduced cytotoxicity, the state refe...

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Detalles Bibliográficos
Autores principales: Zhang, Junfeng, Lei, Feifei, Tan, Huabing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10232978/
https://www.ncbi.nlm.nih.gov/pubmed/37275913
http://dx.doi.org/10.3389/fimmu.2023.1166128