Uncovering the Mechanism of Azepino‐Indole Skeleton Formation via Pictet–Spengler Reaction by Strictosidine Synthase: A Quantum Chemical Investigation

Strictosidine synthase (STR) catalyzes the Pictet–Spengler (PS) reaction of tryptamine and secologanin to produce strictosidine. Recent studies demonstrated that the enzyme can also catalyze the reaction of non‐natural substrates to form new alkaloid skeletons. For example, the PS condensation of 1H...

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Detalles Bibliográficos
Autores principales: Mou, Mingqi, Zhang, Chenghua, Zhang, Shiqing, Chen, Fuqiang, Su, Hao, Sheng, Xiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233217/
https://www.ncbi.nlm.nih.gov/pubmed/37248801
http://dx.doi.org/10.1002/open.202300043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233217/
https://www.ncbi.nlm.nih.gov/pubmed/37248801
http://dx.doi.org/10.1002/open.202300043

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