Application of 2D EXSY and qNMR Spectroscopy for Diastereomeric Excess Determination Following Chiral Resolution of β‐Lactams

Trans‐β‐lactam isomers have garnered much attention as anti‐cancer microtubule targeting agents. Currently available synthetic methods are available for the preparation of enantiopure β‐lactams and favour isomeric cis/trans β‐lactam mixtures. Indirect chiral resolution offers the opportunity for iso...

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Detalles Bibliográficos
Autores principales: McLoughlin, Eavan C., O'Brien, John E., Trujillo, Cristina, Meegan, Mary J., O'Boyle, Niamh M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233219/
https://www.ncbi.nlm.nih.gov/pubmed/35876400
http://dx.doi.org/10.1002/open.202200119

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233219/
https://www.ncbi.nlm.nih.gov/pubmed/35876400
http://dx.doi.org/10.1002/open.202200119

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