Cargando…

Polygenic Risk Score in African populations: progress and challenges

Polygenic Risk Score (PRS) analysis is a method that predicts the genetic risk of an individual towards targeted traits. Even when there are no significant markers, it gives evidence of a genetic effect beyond the results of Genome-Wide Association Studies (GWAS). Moreover, it selects single nucleo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Adam, Yagoub, Sadeeq, Suraju, Kumuthini, Judit, Ajayi, Olabode, Wells, Gordon, Solomon, Rotimi, Ogunlana, Olubanke, Adetiba, Emmanuel, Iweala, Emeka, Brors, Benedikt, Adebiyi, Ezekiel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	F1000 Research Limited 2023
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233318/ https://www.ncbi.nlm.nih.gov/pubmed/37273966 http://dx.doi.org/10.12688/f1000research.76218.2

Ejemplares similares

SysBiolPGWAS: simplifying post-GWAS analysis through the use of computational technologies and integration of diverse omics datasets
por: Falola, Oluwadamilare, et al.
Publicado: (2022)

The interplay of post-translational modification and gene therapy
por: Osamor, Victor Chukwudi, et al.
Publicado: (2016)

Anopheles gambiae Trehalase Inhibitors for Malaria Vector Control: A Molecular Docking and Molecular Dynamics Study
por: Adedeji, Eunice O., et al.
Publicado: (2022)

Anopheles metabolic proteins in malaria transmission, prevention and control: a review
por: Adedeji, Eunice Oluwatobiloba, et al.
Publicado: (2020)

New Insights into the Genetic Regulation of Plasmodium Falciparum Obtained by Bayesian Modeling
por: Bulashevska, Svetlana, et al.
Publicado: (2007)

In Silico Gene Regulatory Network of the Maurer’s Cleft Pathway in Plasmodium falciparum
por: Isewon, Itunuoluwa, et al.
Publicado: (2015)

Correlation Between Body Mass Index and Waist Circumference in Nigerian Adults: Implication as Indicators of Health Status
por: Chinedu, Shalom Nwodo, et al.
Publicado: (2013)

Gene Expression Profiling Analysis Reveals Putative Phytochemotherapeutic Target for Castration-Resistant Prostate Cancer
por: Rotimi, Solomon Oladapo, et al.
Publicado: (2019)

Personalizing medicine in Africa: current state, progress and challenges
por: Owolabi, Paul, et al.
Publicado: (2023)

The H3ABioNet helpdesk: an online bioinformatics resource, enhancing Africa’s capacity for genomics research
por: Kumuthini, Judit, et al.
Publicado: (2019)

In silico Structure Prediction, Molecular Docking, and Dynamic Simulation of Plasmodium falciparum AP2-I Transcription Factor
por: Oladejo, David O, et al.
Publicado: (2023)

Homology Modelling and Molecular Docking Studies of Selected Substituted Benzo[d]imidazol-1-yl)methyl)benzimidamide Scaffolds on Plasmodium falciparum Adenylosuccinate Lyase Receptor
por: Oduselu, Gbolahan O, et al.
Publicado: (2019)

Pharmacophore-Aided Virtual Screening and Molecular Dynamics Simulation Identifies TrkB Agonists for Treatment of CDKL5-Deficiency Disorders
por: Ademuwagun, Ibitayo Abigail, et al.
Publicado: (2023)

Mathematical modeling of malaria transmission dynamics in humans with mobility and control states
por: Adegbite, Gbenga, et al.
Publicado: (2023)

Voltage Gated Sodium Channel Genes in Epilepsy: Mutations, Functional Studies, and Treatment Dimensions
por: Ademuwagun, Ibitayo Abigail, et al.
Publicado: (2021)

Performing post-genome-wide association study analysis: overview, challenges and recommendations
por: Adam, Yagoub, et al.
Publicado: (2021)

High-depth African genomes inform human migration and health
por: Choudhury, Ananyo, et al.
Publicado: (2020)

Potential Anti-Cancer Flavonoids Isolated From Caesalpinia bonduc Young Twigs and Leaves: Molecular Docking and In Silico Studies
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2019)

Author Correction: High-depth African genomes inform human migration and health
por: Choudhury, Ananyo, et al.
Publicado: (2021)

In Vitro Experimental Assessment of Ethanolic Extract of Moringa oleifera Leaves as an α-Amylase and α-Lipase Inhibitor
por: Ogundipe, Adebanke, et al.
Publicado: (2022)

Model Optimization and In Silico Analysis of Potential Dipeptidyl Peptidase IV Antagonists from GC-MS Identified Compounds in Nauclea latifolia Leaf Extracts
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2019)

Bioinformatics Education—Perspectives and Challenges out of Africa
por: Tastan Bishop, Özlem, et al.
Publicado: (2015)

Fermentation Enhanced Biotransformation of Compounds in the Kernel of Chrysophyllum albidum
por: Odutayo, Oluwatofunmi E., et al.
Publicado: (2020)

Anti-inflammatory Mechanism of Ruzu Bitters on Diet-Induced Nonalcoholic Fatty Liver Disease in Male Wistar Rats
por: Ogunlana, Olubanke O., et al.
Publicado: (2020)

Computational Identification of Metabolic Pathways of Plasmodium falciparum using the k-Shortest Path Algorithm
por: Oyelade, Jelili, et al.
Publicado: (2019)

Increased urinary sodium excretion is associated with systolic blood pressure in first degree relatives of hypertensive patients in Ibadan, Southwestern Nigeria
por: Ajayi, Samuel, et al.
Publicado: (2018)

An Estimate of the Incidence of Prostate Cancer in Africa: A Systematic Review and Meta-Analysis
por: Adeloye, Davies, et al.
Publicado: (2016)

Counteractive role of Terminalia catappa leaf extract on hematological and coagulation disturbance in Type 2 diabetic rats
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2023)

Structural Transformation and Creativity Induced by Biological Agents during Fermentation of Edible Nuts from Terminalia catappa
por: Odutayo, Oluwatofunmi E., et al.
Publicado: (2021)

The clinical utility of polygenic risk scores in genomic medicine practices: a systematic review
por: Kumuthini, Judit, et al.
Publicado: (2022)

Terminalia catappa Extract Palliates Redox Imbalance and Inflammation in Diabetic Rats by Upregulating Nrf-2 Gene
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2021)

Improved Classification of Lung Cancer Using Radial Basis Function Neural Network with Affine Transforms of Voss Representation
por: Adetiba, Emmanuel, et al.
Publicado: (2015)

Lung Cancer Prediction Using Neural Network Ensemble with Histogram of Oriented Gradient Genomic Features
por: Adetiba, Emmanuel, et al.
Publicado: (2015)

GC-MS Analysis and Inhibitory Evaluation of Terminalia catappa Leaf Extracts on Major Enzymes Linked to Diabetes
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2019)

Nauclea latifolia Sm. Leaf Extracts Extenuates Free Radicals, Inflammation, and Diabetes-Linked Enzymes
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2020)

Alignment-Free Z-Curve Genomic Cepstral Coefficients and Machine Learning for Classification of Viruses
por: Adetiba, Emmanuel, et al.
Publicado: (2018)

Type 2 Diabetes Mellitus Mediation by the Disruptive Activity of Environmental Toxicants on Sex Hormone Receptors: In Silico Evaluation
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2021)

Terminalia catappa aqueous leaf extract reverses insulin resistance, improves glucose transport and activates PI3K/AKT signalling in high fat/streptozotocin-induced diabetic rats
por: Iheagwam, Franklyn Nonso, et al.
Publicado: (2022)

Polygenic Prediction of Type 2 Diabetes in Africa
por: Chikowore, Tinashe, et al.
Publicado: (2022)

Associations of cardiometabolic polygenic risk scores with cardiovascular disease in African Americans
por: Tsegaselassie, Workalemahu, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_mgf6s473sbo2uh52v2dsnndvb5