BLEACH&STAIN 15-marker Multiplexed Imaging in 3,098 Human Carcinomas Reveals Six Major PD-L1–driven Immune Phenotypes with Distinct Spatial Orchestration

Multiplex fluorescence IHC (mfIHC) approaches were yet either limited to six markers or limited to a small tissue size that hampers translational studies on large tissue microarray cohorts. Here we have developed a BLEACH&STAIN mfIHC method that enabled the simultaneous analysis of 15 biomarkers...

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Detalles Bibliográficos
Autores principales: Bady, Elena, Möller, Katharina, Mandelkow, Tim, Raedler, Jonas B., Yang, Cheng, Ebner, Julia, Lurati, Magalie C.J., Simon, Ronald, Vettorazzi, Eik, Büscheck, Franziska, Luebke, Andreas M., Dum, David, Menz, Anne, Sauter, Guido, Höflmayer, Doris, Weidemann, Sören, Fraune, Christoph, Uhlig, Ria, Bernreuther, Christian, Jacobsen, Frank, Clauditz, Till S., Wilczak, Waldemar, Burandt, Eike, Steurer, Stefan, Minner, Sarah, Lennartz, Maximilian, Blessin, Niclas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Tumor Microenvironment and Immunobiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233353/
https://www.ncbi.nlm.nih.gov/pubmed/36976297
http://dx.doi.org/10.1158/1541-7786.MCR-22-0593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233353/
https://www.ncbi.nlm.nih.gov/pubmed/36976297
http://dx.doi.org/10.1158/1541-7786.MCR-22-0593

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