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Structure of reverse gyrase with a minimal latch that supports ATP-dependent positive supercoiling without specific interactions with the topoisomerase domain

Reverse gyrase is the only topoisomerase that introduces positive supercoils into DNA in an ATP-dependent reaction. Positive DNA supercoiling becomes possible through the functional cooperation of the N-terminal helicase domain of reverse gyrase with its C-terminal type IA topoisomerase domain. This...

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Detalles Bibliográficos
Autores principales: Mhaindarkar, Vaibhav P., Rasche, René, Kümmel, Daniel, Rudolph, Markus G., Klostermeier, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233626/
https://www.ncbi.nlm.nih.gov/pubmed/37204816
http://dx.doi.org/10.1107/S2059798323002565