Imidazopyridine Amides: Synthesis, Mycobacterium smegmatis CIII(2)CIV(2) Supercomplex Binding, and In Vitro Antimycobacterial Activity

[Image: see text] Q203 (telacebec) is an imidazopyridine amide (IPA) targeting the respiratory CIII(2)CIV(2) supercomplex of the mycobacterial electron transport chain (ETC). Aiming for a better understanding of the molecular mechanism of action of IPA, 27 analogues were prepared through a seven-ste...

Descripción completa

Detalles Bibliográficos
Autores principales: Abdelaziz, Rana, Di Trani, Justin M, Sahile, Henok, Mann, Lea, Richter, Adrian, Liu, Zhongle, Bueler, Stephanie A., Cowen, Leah E., Rubinstein, John L., Imming, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233671/
https://www.ncbi.nlm.nih.gov/pubmed/37273644
http://dx.doi.org/10.1021/acsomega.3c02259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233671/
https://www.ncbi.nlm.nih.gov/pubmed/37273644
http://dx.doi.org/10.1021/acsomega.3c02259

Ejemplares similares