Cargando…

Silibinin, an HSP90 Inhibitor, on Human ACTH-Secreting Adenomas

INTRODUCTION: The glucocorticoid receptor is pivotal to control corticotrophin (ACTH) secretion, and its function is closely linked to the heat shock protein 90 (HSP90) chaperone complex. Impaired sensitivity to glucocorticoid feedback is a hallmark of human corticotroph adenomas, i.e., Cushing'...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pecori Giraldi, Francesca, Cassarino, Maria Francesca, Sesta, Antonella, Lasio, Giovanni, Losa, Marco
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	S. Karger AG 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233703/ https://www.ncbi.nlm.nih.gov/pubmed/36791678 http://dx.doi.org/10.1159/000529710

Ejemplares similares

SAT-308 Effect of Silibinin on ACTH Synthesis and Secretion in Human Adenomatous Corticotropes in Vitro
por: Cassarino, Maria Francesca, et al.
Publicado: (2020)

Sexual Dimorphism in Cellular and Molecular Features in Human ACTH-Secreting Pituitary Adenomas
por: Pecori Giraldi, Francesca, et al.
Publicado: (2020)

Proopiomelanocortin, glucocorticoid, and CRH receptor expression in human ACTH-secreting pituitary adenomas
por: Cassarino, Maria Francesca, et al.
Publicado: (2016)

Role of the ubiquitin/proteasome system on ACTH turnover in rat corticotropes
por: Sesta, Antonella, et al.
Publicado: (2018)

Dual effects of 9-cis retinoic acid on ACTH-dependent hyperplastic adrenal tissues
por: Pecori Giraldi, Francesca, et al.
Publicado: (2021)

Gene expression profiling in human corticotroph tumours reveals distinct, neuroendocrine profiles
por: Cassarino, Maria Francesca, et al.
Publicado: (2018)

Benzene and 2-ethyl-phthalate induce proliferation in normal rat pituitary cells
por: Tapella, Laura, et al.
Publicado: (2016)

Genetic Basis of ACTH-Secreting Adenomas
por: Locantore, Pietro, et al.
Publicado: (2022)

SAT-346 POR Rs2286822 Polymorphism Is Associated with Clinical Features in Patients with Congenital Adrenal Hyperplasia Due to 21 Hydroxylase Deficiency
por: Pecori Giraldi, Francesca, et al.
Publicado: (2019)

Adrenal Adenoma Anarchy: A Case of an ACTH-Secreting Pheochromocytoma
por: Lee, Michelle N., et al.
Publicado: (2020)

SAT-LB90 Angiotensin II and ACTH Receptor Expression in Aldosterone-Producing Adenomas
por: Lim, Jung Soo, et al.
Publicado: (2020)

ICA Occlusion by an ACTH-secreting pituitary adenoma post-TSS and irradiation
por: El-Zammar, Diala, et al.
Publicado: (2011)

PMON129 Pituitary Adenoma Co-Secreting GH, Prolactin and ACTH
por: Wilson, Sarah, et al.
Publicado: (2022)

The Genomic Landscape of Corticotroph Tumors: From Silent Adenomas to ACTH-Secreting Carcinomas
por: Andonegui-Elguera, Sergio, et al.
Publicado: (2022)

Inhibitors of HSP90 in melanoma
por: Mielczarek-Lewandowska, Aleksandra, et al.
Publicado: (2019)

ACTH-dependent Cushing’s Syndrome: Diagnostic Pitfalls in Concomitant Non-secreting Pituitary Adenomas
por: Lucotti, Pietro, et al.
Publicado: (2016)

Integration of Proteomics and Metabolomics Revealed Metabolite–Protein Networks in ACTH-Secreting Pituitary Adenoma
por: Feng, Jie, et al.
Publicado: (2018)

ODP618 The profile of patients with ACTH-secreting pituitary adenomas and subclinical pituitary apoplexy
por: Tatsi, Christina, et al.
Publicado: (2022)

Pasireotide-Induced Shrinkage in GH and ACTH Secreting Pituitary Adenoma: A Systematic Review and Meta-Analysis
por: Mondin, Alessandro, et al.
Publicado: (2022)

Somatostatin analog challenge test in the pre-surgical management of ACTH-secreting pheochromocytoma
por: Rossini, Alessandro, et al.
Publicado: (2019)

Identification of the Plant Compound Geraniin as a Novel Hsp90 Inhibitor
por: Vassallo, Antonio, et al.
Publicado: (2013)

ACTH Secreting Pituitary Tumours
por: Nabarro, J. D. N.
Publicado: (1977)

Lycopene and Beta-Carotene Induce Growth Inhibition and Proapoptotic Effects on ACTH-Secreting Pituitary Adenoma Cells
por: Haddad, Natália F., et al.
Publicado: (2013)

Phenotype-Genotype Association Analysis of ACTH-Secreting Pituitary Adenoma and Its Molecular Link to Patient Osteoporosis
por: Wang, Renzhi, et al.
Publicado: (2016)

Ectopic invasive ACTH-secreting pituitary adenoma mimicking chordoma: a case report and literature review
por: Li, Yan, et al.
Publicado: (2023)

Ectopic sphenoidal ACTH-secreting adenoma revealed by (11)C Methionine PET scan: case report
por: Lurquin, F., et al.
Publicado: (2023)

A human ACTH-secreting corticotroph tumoroid model: Novel Human ACTH-Secreting Tumor Cell in vitro Model
por: Zhang, Dongyun, et al.
Publicado: (2021)

Hsp90 Inhibitors Prevent HSV-1 Replication by Directly Targeting UL42-Hsp90 Complex
por: Qin, Shurong, et al.
Publicado: (2022)

HSP90 inhibitors disrupt a transient HSP90-HSF1 interaction and identify a noncanonical model of HSP90-mediated HSF1 regulation
por: Kijima, Toshiki, et al.
Publicado: (2018)

Upregulation of TGF-β-induced HSP27 by HSP90 inhibitors in osteoblasts
por: Kuroyanagi, Gen, et al.
Publicado: (2022)

ODP338 Neuromedin B Receptor Antagonist Suppresses ACTH Secretion and Cell Proliferation in Human and Mouse Corticotroph Adenoma
por: Atsumi, Tatsuya, et al.
Publicado: (2022)

POR polymorphisms are associated with 21 hydroxylase deficiency
por: Pecori Giraldi, F., et al.
Publicado: (2021)

Phosphorylation in the Charged Linker Modulates Interactions and Secretion of Hsp90β
por: Weidenauer, Lorenz, et al.
Publicado: (2021)

SAT-LB57 The Spectrum of Genomic and Transcriptomic Alterations in ACTH-Producing and ACTH-Silent Corticotroph Adenomas
por: Lerario, Antonio Marcondes, et al.
Publicado: (2020)

Design and Synthesis of Hsp90 Inhibitors with B‐Raf and PDHK1 Multi‐Target Activity
por: Pinzi, Luca, et al.
Publicado: (2021)

Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors
por: Woodford, Mark R., et al.
Publicado: (2016)

Correction: Lycopene and Beta-Carotene Induce Growth Inhibition and Proapoptotic Effects on ACTH-Secreting Pituitary Adenoma Cells
por: Haddad, Natália F., et al.
Publicado: (2016)

ACTH-independent Cushing’s syndrome with bilateral cortisol-secreting adrenal adenomas: a case report and review of literatures
por: Wei, Jia, et al.
Publicado: (2018)

Cryptococcal meningitis after transnasal transsphenoidal pituitary microsurgery of ACTH-secreting pituitary adenoma: A case report
por: Liu, Yang, et al.
Publicado: (2017)

Hsp90 Inhibitors for the Treatment of Chronic Myeloid Leukemia
por: Khajapeer, Kalubai Vari, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_dkd3kava0415hmasqoukje6rvn