Practical Synthesis of 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic Acid—Key Intermediate of Lifitegrast (Xiidra)

[Image: see text] In the present study, a practical method for synthesizing the key intermediate 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1) of Lifitegrast was proposed. First, an investigation was conducted into the utilization of the impurity and recrystallization method in the synthe...

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Detalles Bibliográficos
Autores principales: Liu, Xu, Guo, Heng, Peng, Peng, Li, Yaping, Yang, Jiangtao, Wu, Chuanjun, Xu, Shengjun, Zhao, Chuanmeng, Zhang, Fuli
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233828/
https://www.ncbi.nlm.nih.gov/pubmed/37273640
http://dx.doi.org/10.1021/acsomega.3c02188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10233828/
https://www.ncbi.nlm.nih.gov/pubmed/37273640
http://dx.doi.org/10.1021/acsomega.3c02188

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