Differential effects of familial Alzheimer’s disease-causing mutations on amyloid precursor protein (APP) trafficking, proteolytic conversion, and synaptogenic activity

The amyloid precursor protein (APP) is a key player in Alzheimer`s disease (AD) and the precursor of the Aβ peptide, which is generated by consecutive cleavages of β- and γ-secretases. Familial Alzheimer’s disease (FAD) describes a hereditary subgroup of AD that represents a low percentage of AD cas...

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Detalles Bibliográficos
Autores principales: Schilling, Sandra, Pradhan, Ajay, Heesch, Amelie, Helbig, Andrea, Blennow, Kaj, Koch, Christian, Bertgen, Lea, Koo, Edward H., Brinkmalm, Gunnar, Zetterberg, Henrik, Kins, Stefan, Eggert, Simone
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234039/
https://www.ncbi.nlm.nih.gov/pubmed/37259128
http://dx.doi.org/10.1186/s40478-023-01577-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234039/
https://www.ncbi.nlm.nih.gov/pubmed/37259128
http://dx.doi.org/10.1186/s40478-023-01577-y

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