The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function

Vascular endothelial growth factor receptor 2 (VEGFR2, encoded by KDR) regulates endothelial function and angiogenesis. VEGFR2 undergoes ubiquitination that programs this receptor for trafficking and proteolysis, but the ubiquitin-modifying enzymes involved are ill-defined. Herein, we used a reverse...

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Detalles Bibliográficos
Autores principales: Critchley, William R., Smith, Gina A., Zachary, Ian C., Harrison, Michael A., Ponnambalam, Sreenivasan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234107/
https://www.ncbi.nlm.nih.gov/pubmed/37226882
http://dx.doi.org/10.1242/jcs.260657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234107/
https://www.ncbi.nlm.nih.gov/pubmed/37226882
http://dx.doi.org/10.1242/jcs.260657

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