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Cell-based optimization and characterization of genetically encoded location-based biosensors for Cdc42 or Rac activity

Rac (herein referring to the Rac family) and Cdc42 are Rho GTPases that regulate the formation of lamellipoda and filopodia, and are therefore crucial in processes such as cell migration. Relocation-based biosensors for Rac and Cdc42 have not been characterized well in terms of their specificity or...

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Detalles Bibliográficos
Autores principales: Mahlandt, Eike K., Kreider-Letterman, Gabriel, Chertkova, Anna O., Garcia-Mata, Rafael, Goedhart, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234108/
https://www.ncbi.nlm.nih.gov/pubmed/37226883
http://dx.doi.org/10.1242/jcs.260802