Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFR(WT/)EGFR(T790M) inhibitors

A new series of indole-2-carboxamides 5a-g, 6a-f and pyrido[3,4-b]indol-1-ones 7a and 7b have been developed as new antiproliferative agents that target both wild and mutant type EGFR. The antiproliferative effect of the new compounds was studied. 5c, 5d, 5f, 5 g, 6e, and 6f have the highest antipro...

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Detalles Bibliográficos
Autores principales: Al-Wahaibi, Lamya H., Mohammed, Anber F., Abdel Rahman, Fatema El-Zahraa S., Abdelrahman, Mostafa H., Gu, Xuyuan, Trembleau, Laurent, Youssif, Bahaa G. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234138/
https://www.ncbi.nlm.nih.gov/pubmed/37254958
http://dx.doi.org/10.1080/14756366.2023.2218602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10234138/
https://www.ncbi.nlm.nih.gov/pubmed/37254958
http://dx.doi.org/10.1080/14756366.2023.2218602

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